Talk:Monoclonal antibody

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Untitled

The section about the purification of monoclonal antibodies could use some references.Bassmaster1137 (talk) 07:27, 18 December 2008 (UTC)[reply]

The

The title doesn't make sense in the singular "Monoclonal antibody", so I moved to the plural. AxelBoldt 14:55, 24 Mar 2004 (UTC)

Request for section

Could you consider adding if not a section then a sentence or two about chimeric antibodies and humanized antibodies? I put up an item at 1986 in science that would benefit from a linkage to this concept/process. Thanks. Courtland 19:58, 2005 Feb 21 (UTC)

It's better now. I've added Greg Winter's discovery of humanised monoclonal antibodies in 1988. JFW | T@lk 23:06, 7 November 2005 (UTC)[reply]

--- would it be possible to add one of our findings, more info: Monoclonal Antibodies Specific to Cooked Meats, http://logikbase.com/website/techprofile.cfm?licid=639, our contact: techtransferportal@yahoo.com

Title

As noted above, I tried to move the article to "Monoclonal antibodies" once before, but it was moved back. I understand that Wikipedia policy requires article titles to be in the singular, but this appears to be a valid exception: the title in the singular makes little sense; the adjective "monoclonal", just like "identical", cannot modify a singular noun. If there is no opposition, I would therefore like to move the article back. AxelBoldt 17:57, 23 November 2005 (UTC)[reply]

Shouldn't be a problem. JFW | T@lk 18:05, 23 November 2005 (UTC)[reply]

I don't agree with the reasoning for the plural title. "identical" is commonly used to modify singular nouns, such as in "identical twin". A twin is one of a pair, thus singular. The same applies to "monoclonal antibody". It identifies one member of a group. --Blainster 19:13, 5 October 2006 (UTC)[reply]

Surely, everybody calls them Monoclonal Antibodies in general and Monoclonal Antibody when refering to a specified clone.

GrahamColm 16:31, 30 September 2007 (UTC)[reply]

Request for section: Herceptin

Herceptin is the comercial name for monoclonal Antibodies against the Erb-B2 (an Epidermal Grotwh Factor Receptor) often found over-expressed on cancers and used as treatment for those cancers. This is an important example of monoclonal antibodies. http://www.herceptin.com/herceptin/patient/metastatic/herceptin.jsp --JamMan 07:43, 14 May 2007 (UTC)[reply]

Clone?

First sentence: How can a monoclonal antibody be a clone of a cell? An antibody is a peptide, not a cell. --aciel 23:51, 9 October 2007 (UTC)[reply]

a cell could be an antibody —Preceding unsigned comment added by 74.71.99.140 (talk) 14:10, 18 February 2009 (UTC)[reply]

WikiProject class rating

This article was automatically assessed because at least one WikiProject had rated the article as start, and the rating on other projects was brought up to start class. BetacommandBot 16:30, 10 November 2007 (UTC)[reply]

Changes in Hybridoma cell production

The de novo pathway is the one which is blocked by Aminopterin, not the alternate (salvage) pathway. I have changed it. The alternate pathway is the salvage pathway, the one where HGPRT is needed. Proquence (talk) 15:56, 25 November 2008 (UTC)[reply]

Image:MonoclonalAb.jpg

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Changed it.Murdochious (talk) 15:46, 3 May 2009 (UTC)[reply]

Time and cost

How long does it take to obtain a monoclonal antibody? Is it a matter of months or years?

Also, are there studies evaluating the cost of designing such an antibody? I gess it must vary a lot depending on the target protein, but is it a matter of thousands or millions dollars? Calimo (talk) 07:57, 3 June 2009 (UTC)[reply]

I added a cost section. Also, see https://www.researchgate.net/post/What_is_the_best_and_cheapest_protocol_for_monoclonal_antibody_production. --50.201.195.170 (talk) 00:39, 29 May 2020 (UTC)[reply]

Incorrect description

The text under the third illustration reads: "Monoclonal antibodies can be grown in unlimited quantities in the bottles shown in this picture." This is not correct, antibodies does not "grow" themselves or produce new antibodies. Cells do produce antibodies and cells can (probably) be grown in such flasks. "Unlimited quantities" is also very questionable. — Preceding unsigned comment added by Eskilt (talk • contribs) 08:54, 17 January 2011 (UTC)[reply]

Copyright problem removed

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copyvio

just deleted text in this dif which was copyvio from here Jytdog (talk) 01:59, 20 September 2014 (UTC)[reply]

Updating Applications

This edit request by an editor with a conflict of interest was declined. v

We detected some elements that we would like to update: 1. Include EMA in the following sentence: "MAbs approved by the FDA and EMA include" ^[1] 2. Update the application content for cetuximab: "Approved in head and neck squamous cell carcinomas, metastatic colorectal carcinoma" 3. Under References we would suggest to substitute 34. Takimoto... with "U.S. Food and Drug Administration. “FDA Approved Drug Products.” 2015–11–16."^[2] Furthermore, adding the reference "European Medicines Agency. Medicines. 2015–11–16." ^[3]

References

If there are no doubts concerning those chnages, I would like to implement them. best regards Florian Schaub at Merck KGaA (talk) 15:48, 22 January 2016 (UTC)[reply]

Dear all, could you give any feedback concerning my request? If you have no doubts, I would lik eto upload them. Best regards, Florian Schaub at Merck KGaA (talk) 16:18, 12 February 2016 (UTC)[reply]

Not done. 1. This doesn't work with the sentence, which is about 2005 approvals by the FDA. Please propose a more specific change, since there are presumably several Monoclonal antibodies approved by the EMA. 2. No reliable source is provided for this case. 3. Where in the article should this be content be included? ---- Patar knight - ^chat/_{contributions} 16:26, 18 November 2016 (UTC)[reply]

Faulty Citation Link

The link to source 37 from Peregrine Pharmaceuticals does not work. When you click on it you will be redirected to an error page that says component not found. This source was used to explain the use of a monoclonal anti-body, bavituximab, as an anti-cancer and anti-viral treatment. Either the link should be fixed or another source with the same information should be found.Dbarsa (talk) 05:14, 12 February 2016 (UTC)[reply]

thanks, i fixed it Jytdog (talk) 06:21, 12 February 2016 (UTC)[reply]

Fake content

So in this dif an IP that has made only two edits added unsourced content. It is apparently fake. That was 24 November 2015 It was removed today by another IP that has made only one edit. So for three and a half months we had pure garbage in our article. Jytdog (talk) 19:10, 12 March 2016 (UTC)[reply]

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Request for a New Section: Naming Convention for mAbs

It looks the naming convention for mAbs is missing. Can you please add that. Thanks! — Preceding unsigned comment added by PaulSpecial (talk • contribs) 09:27, 9 September 2020 (UTC)[reply]

Proposed External Link

I would like to add a link to help people find monclonal antibodies for COVID-19. The HHS has a website that can be found here: https://protect-public.hhs.gov/pages/therapeutics-distribution

Edit: Make COVID-19 Use More Pronounced

I have added a subsection with a short description discussing the application to COVID-19. I was thinking that because of the importance of the pandemic and the potential benefit or even misinformation of monoclonal antibodies, this should be expanded upon and become an entire section of its own.

Daratumumab

Daratumumab, ..., is an anti-cancer monoclonal antibody medication. It binds to CD38, which is overexpressed in multiple myeloma cells. (from the article header). So it should be in the anti-cancer list, but doesn't quite fit, the description of the protein expressed only(?) by the cancer cells as I understand it. A nuanced description of what the antibodies are targeting is needed, but someone knowledgeable on the subject (or a good quotation). RDBrown (talk) 09:50, 2 September 2024 (UTC)[reply]

[1] ttp://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/landing/epar_search.jsp&mid=WC0b01ac058001d124

[2] ttp://www.accessdata.fda.gov/scripts/cder/drugsatfda/index.cfm

[3] ttp://www.ema.europa.eu/ema/index.jsp?curl=pages/includes/medicines/medicines_landing_page.jsp

[1]

[2]

[3]